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Anticoagulated guinea pig blood suitable for use in complement titration, adsorption procedures, testing for agglutinins/HA assays, and the preparation of stroma as particulate reagents.
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An intermediate in aromatic amino acid metabolism; inhibits LPS-induced IL-6 and NO production in RAW 264.7 macrophages (IC50s = 2 and 0.5 mM, respectively); decreases serum starvation-induced mitochondrial superoxide production in EA.hy926 endothelial cells in vitro; increases survival in a rat model of hemorrhagic shock; serum and urinary levels are increased in patients with alkaptonuria
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A prochiral substrate; an esterified derivative of 3-hydroxyglutaric acid; used to characterize the ability of a lipase from C. antarctica to catalyze aminolysis of prochiral substrates
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A perfluoroalkyl substance; activates PPARα in a reporter assay using COS-1 cells expressing the human or mouse receptor from 5-100 µM; has been found in landfill leachate and sea and river water
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A partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay); induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle; completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs (5 mg/kg); reverses the antitussive effect of baclofen in cats (3 mg/kg)
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A methyl ester form of cis-vaccenic acid; inhibits sodium influx in mouse brain synaptic plasma membranes, which is correlated with an increase in membrane lipid disordering; has been used as an internal standard for the quantification of cis-vaccenic acid
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