Guinea Pig Whole Blood
Cayman Chemical 13 ZDocosenoIc ACD methyl
The main component (80 ) of ivermectin binds to glutamate-gated chloride channels inducing irreversible channel opening ivermectin inhibits replication of SARS-CoV-2 in Vero/hSLAM cells
Cayman Chemical VIldaglIptIn carboxylIc ACD
An inhibitor of VEGFR2 (IC50 0 0027 M for the human receptor) selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s 1 5 1 7 and 1 1 M respectively) as well as 40-fold selective over B-RAF RET and Tie2 inhibits VEGF-induced proliferation of HUVECs (IC50 0 01 nM) inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice at 1 and 3 mg/kg per day inhibits primary tumor and metastasis growth in a B16 melanoma mouse model at 3 mg/kg per day
Cayman Chemical GlycoursodeoxycholIc ACD 250mg
A P-gp inhibitor inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 0 05 UM) inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s 73 and 9 3 UM respectively) enhances growth inhibition of MCF-7/ADR breast cancer cells at 2 or 20 UM when used in combination with doxorubicin in vitro but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 UM
Cayman Chemical ShortchaIn Faty ACD MaxSpe 1ea
A reversible inhibitor of Lp-PLA2 (IC50 0.25 nM) that produces sustained inhibition of plasma Lp-PLA2 activity in humans
Cayman Chemical DocosahexaenoIc ACD Alkyn
A long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture included in media to enhance the survival of human embryonic stem cells or drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells
Cayman Chemical EIcosapentaenoIc ACD Alkyn
A macrolide antibiotic inhibits 50S ribosome activity active against a host of bacterial genera including Streptococcus Staphylococcus and Haemophilus (MIC90s 0.015-2.0 mg/l) dose-dependently inhibits the growth of S. aureus in a mouse model of thigh infection at 10-40 mg/kg inhibits CYP3A4 (IC50s 33 and 27.3 UM for a-hydroxytriazolam and 4-hydroxytriazolam formation respectively)
Cayman Chemical PRfluoropropnsulfonIc ACD
A BTK inhibitor (IC50s 10-100 and C481S respectively) selective for BTK over EGFR (IC50 1-10 UM) decreases the number of Ki67-positive cells in MEC-1 CLL mouse xenograft models using MEC-1 cells that express either wild-type BTK or BTKC481S
Cayman Chemical DocosahexaenoIc ACD ethyl S
An activator of KATP channels induces relaxation of potassium-precontracted isolated guinea pig bladder detrusor muscle strips (EC50 0.5 UM) reduces bladder overactivity in a rat model of ligature-intact partial urethral obstruction
Cayman Chemical EIcosapentaenoIc ACD ethyl50ug
A FAAH inhibitor (IC50s 0.028 and 0.1 UM for the human and rat enzymes respectively)
Cayman Chemical DocosahexaenoIc ACD ethyl S
An activator of KATP channels induces relaxation of potassium-precontracted isolated guinea pig bladder detrusor muscle strips (EC50 0.5 UM) reduces bladder overactivity in a rat model of ligature-intact partial urethral obstruction
Cayman Chemical DocosahexaenoIc ACD ethyl50UG
A urotensin II receptor antagonist (Kis 61 17 30 65 and 56 nM for the human monkey cat rat and mouse receptors respectively) reduces urotensin II-induced increases in the expression of IL1B IL6 and VCAM1 in EA.hy926 cells at 1 UM reduces urotensin II-induced adhesion of U937 monocytes to EA.hy926 cells at 1 UM
Cayman Chemical aLInolenIc ACD methyl STR
A polyphenol with diverse biological activities inhibits PDE4D2 and PDE4B2 (IC50s 1.9 and 4.5 UM respectively) induces cell death in P388 cells (IC50 24.8 UM) inhibits IL-1B-induced increases in the levels of phosphorylated ERK and JNK in A549 cells at 30 or 50 UM inhibits LPS-induced increases in NO and iNOS levels in MH-S macrophages at 50 and 60 UM respectively inhibits LPS-induced increases in the number of neutrophils alveolar macrophages and dendritic cells in BALF the thickness of alveolar walls and the levels of NF-KB in the lungs in a rat model of acute lung injury at 60 mg/kg
Cayman Chemical DocosahexaenoIc ACD ethyl50mg
A TEAD1 inhibitor (IC50 1.02 nM) inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2 TEAD3 or TEAD4 at 3 UM inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 cells reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models
Cayman Chemical EIcosapentaenoIc ACD ethyl1mg
An ALDH1A3 inhibitor (IC50 5.14 nM) potentiates glucose-induced insulin secretion from pancreatic islets isolated from patients with type 2 diabetes at 10 UM decreases plasma insulin levels and reduces blood glucose levels in an IPGTT in diabetic db/db male mice at 40 mg/kg per day decreases blood glucose levels and increases plasma insulin levels in a mouse model of high-fat diet-induced obesity at 270 ppm in the diet
Cayman Chemical ArachIdonIc ACD sulfonatS
An M4 muscarinic receptor PAM selective for M4 mAChRs over a panel of 59 receptors ion channels transporters and enzymes at 10 UM selectively potentiates ACh-induced activation of the M4 mAChR over M1-M3 and M5 mAChRs in cells expressing the human receptors (EC50s 12.3 4798 >10000 >10000 and >10000 nM respectively) inhibits amphetamine-induced locomotor activity in mice and prepulse inhibition deficits in rats at 3.2 mg/kg